Antiepileptik �la�lar�n Kemik Yo�unlu�una ve Metabolizmas�na Etkileri

ISSN 1300-7157

Anasayfa | �leti�im

Cilt : 27 Say� : 1 Y�l: 2021

Antiepileptik �la�lar�n Kemik Yo�unlu�una ve Metabolizmas�na Etkileri [Epilepsi]

Epilepsi. 2017; 23(1): 1-6 | DOI: 10.14744/epilepsi.2016.93723

Antiepileptik �la�lar�n Kemik Yo�unlu�una ve Metabolizmas�na Etkileri

Zeynep Ayd�n �zemir, Ay�e Dest�n� Yal��n
Sa�l�k Bilimleri �niversitesi, �mraniye E�itim ve Ara�t�rma Hastanesi, N�roloji Klini�i

Epilepsi ve epilepsi tedavisine y�nelik ila�lar�n kemik mineralizasyonunu ve kalsiyum metabolizmas�na etki etti�ine dair kan�tlar giderek artmaktad�r. Klasik (fenobarbital, karbamazepin, VPA vs) ve baz� yeni antiepileptik ila�lar (okskarbazepin, gabapentin) ile belirgin kemik mineral yo�unlu�unda azalma bir�ok �al��mada g�sterilmi�tir. Kalsiyum metabolizmas�ndaki anormalilerin baz� antiepileptiklerin sitokrom P450 enzim sistemini ind�kleyici etkileri ve b�ylece D vitamini d�zeylerini azaltmalar� ile ortaya ��kt�� d��n�lmektedir. Ancak VPA gibi bu sistemi bask�layan veya bu sisteme etki etmeyen antiepileptiklerin vitamin D metabolizmas�na nas�l etki ettikleri bilinmemektedir. Bu yaz�da, klasik ve yeni antiepileptik ila�lar�n kemik sa�l�� ve kalsiyum metabolizmas�na etkileri g�zden ge�irildi.

Anahtar Kelimeler: Antiepileptik ila�lar, kalsiyum metabolizmas�, kemik mineral yo�unlu�unda azalma.

The Effects of Antiepileptic Drugs on Bone Density and Metabolism

Zeynep Ayd�n �zemir, Ay�e Dest�n� Yal��n
University of Health Sciences, �mraniye Research and Education Hospital, Department of Neurology

Proof that epilepsy and antiepileptic drugs affect bone mineral metabolism has increased. It has been demonstrated in many studies that both classic (e.g., phenobarbital, carbamazepine, valproate) and new antiepileptic drugs (e.g., oxcarbamazepine, gabapentin) decrease bone metabolism. Abnormalities in calcium metabolism often occur as result of inducing the cytochrome p450 enzyme system, and thus decreasing vitamin D level. However, the reason some antiepileptic drugs that suppress (e.g., valproate) or have no effect on this system also affect vitamin D metabolism is not known. In this article, the effect of classic and new antiepileptic drugs on bone health and calcium metabolism is reviewed.

Keywords: Antiepileptic drugs, calcium metabolism, decrease in bone mineral density.

Zeynep Ayd�n �zemir, Ay�e Dest�n� Yal��n. The Effects of Antiepileptic Drugs on Bone Density and Metabolism. Epilepsi. 2017; 23(1): 1-6

Sorumlu Yazar: Zeynep Ayd�n �zemir, T�rkiye

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